Copyright
©The Author(s) 2005.
World J Gastroenterol. Jul 21, 2005; 11(27): 4188-4193
Published online Jul 21, 2005. doi: 10.3748/wjg.v11.i27.4188
Published online Jul 21, 2005. doi: 10.3748/wjg.v11.i27.4188
Table 3 Distribution of CTLA4 genotypes among study subjects
| Polymorphic site | Genotype | Number (%) of subjects with genotype | Controls (n = 200) | |
| UC (n = 108) | CD (n = 79) | |||
| nt –318 | C/C | 84 (77.8) | 63 (79.8) | 163 (81.5) |
| C/T | 24 (22.2) | 14 (17.7) | 36 (18.0) | |
| T/T | 0 | 2 (2.5) | 1 (0.5) | |
| nt +49 | A/A | 14 (13) | 9 (11.4) | 33 (16.5) |
| A/G | 56 (51.8) | 41 (51.9) | 93 (46.5) | |
| G/G | 38 (35.2) | 29 (36.7) | 74 (37.0) | |
| nt +6 230 | G/G | 54 (50) | 39 (49.4) | 100 (50.0) |
| G/A | 50 (46.3) | 37 (46.8) | 78 (39.0) | |
| A/A | 4 (3.7) | 3 (3.8) | 22 (11.0) | |
| (AT)n in 3’-UTR | (AT)7/(AT)7 | 52 (48.1) | 41 (51.9) | 101 (50.5) |
| (AT)7/(AT)15 | 2 (1.9) | 1 (1.3) | 1 (0.5) | |
| (AT)7/(AT)16 | 1 (0.9) | 0 | 2 (1.0) | |
| (AT)15/(AT)15 | 16 (14.8 | 5 (6.3) | 31 (15.5) | |
| (AT)15/(AT)16 | 11 (10.2) | 9 (11.4) | 18 (9.0) | |
| (AT)15/(AT)17 | 0 | 2 (2.5) | 1 (0.5) | |
| (AT)16/(AT)16 | 18 (16.7) | 13 (16.4) | 30 (15.0) | |
| (AT)16/(AT)17 | 2 (1.9) | 0 | 6 (3.0) | |
| (AT)16/(AT)18 | 0 | 0 | 1 (0.5) | |
| (AT)17/(AT)17 | 0 | 6 (7.6) | 3 (1.5) | |
| (AT)17/(AT)18 | 1 (0.9) | 1 (1.3) | 3 (1.5) | |
| (AT)18/(AT)18 | 5 (4.6) | 0 | 2 (1.0) | |
| (AT)20/(AT)20 | 0 | 1 (1.3) | 0 | |
| (AT)22/(AT)22 | 0 | 0 | 1 (0.5) | |
- Citation: Machida H, Tsukamoto K, Wen CY, Narumi Y, Shikuwa S, Isomoto H, Takeshima F, Mizuta Y, Niikawa N, Murata I, Kohno S. Association of polymorphic alleles of CTLA4 with inflammatory bowel disease in the Japanese. World J Gastroenterol 2005; 11(27): 4188-4193
- URL: https://www.wjgnet.com/1007-9327/full/v11/i27/4188.htm
- DOI: https://dx.doi.org/10.3748/wjg.v11.i27.4188