Gastrin and antral G cells in course of Helicobacter pylori eradication: Six months follow up study

Table 3 Ultrastructural characteristics of antral G cell in dyspeptic patients before and after therapy assessed by electron microscopy morphometric study

Antral G cell	H pylori+Ge	H pylori+Gne	H pylori+DU	CG1	CG2	P
	(n = 24)	(n = 7)	(n = 8)	(n = 11)	(n = 7)
Number of cells analyzed
Before therapy	93	30	33	55	37
After therapy	113	31	30	47
Cell profile surface (μm2)
Before therapy	142 ± 14	138 ± 20	188 ± 14a	130 ± 10	136 ± 10	0.05a
After therapy	140 ± 15	133 ± 12	138 ± 10d	133 ± 12	/	NS
P	NS	NS	0.001d	NS	/
Endoplasmatic reticulum (μm2) (profile surface)
Before therapy	6.9 ± 2.3a	6.2 ± 2.3	17.9 ± 2.3b	5.3 ± 0.9	5.5 ± 0.9	a0.05;b0.01
After therapy	5.0 ± 2.3	6.0 ± 1.0	5.7 ± 1.3d	5.5 ± 0.7		NS
P	NS	NS	0.001d	NS
Volumen density of cytoplasmic granules
Before therapy	17.3 ± 1.9a	13.1 ± 3.2	47.0 ± 4.9b	14.6 ± 2.7	13.6 ± 2.7	a0.05;b0.01
After therapy	9.7 ± 1.1b	14.2 ± 3.1	17.3 ± 1.9	13.2 ± 2.0	/	NS
P	0.01b	NS	NS	NS	/
Number of cytoplasmic granules/cell profile
Before therapy	232 ± 18a	199 ± 34	330 ± 13b	190 ± 37	196 ± 21	a0.05;b0.01
After therapy	180 ± 13	202 ± 45	220 ± 31	196 ± 20	/	NS
P	NS	NS	NS	NS	/
Mean diameter of cytoplasmic granules (nm)
Before therapy	220 ± 23	245 ± 11	327 ± 23a	237 ± 4	227 ± 7	0.01a
After therapy	223 ± 23	229 ± 22	257 ± 21b	223 ± 9	/	NS
P	NS	NS	0.01b	NS	/
Golgi apparatus (μm2) (profile surface)
Before therapy	2.9 ± 0.10b	2.10 ± 0.3	3.33 ± 0.10a	2.11 ± 0.33	2.05 ± 0.23	0.01a
After therapy	2.15 ± 0.10	2.23 ± 0.2	2.20 ± 0.11b	2.20 ± 0.22	/	NS
P	0.01b	NS	0.01b	NS	/

^aP<0.05,

^bP<0.01,

^dP<0.001 vs others.