Lansoprazole prevents experimental gastric injury induced by non-steroidal anti-inflammatory drugs through a reduction of mucosal oxidative damage

Figure 2 Histomorphometric evaluation of gastric mucosal damage in rats subjected to intragastric administration of indomethacin (IND, 100 µmol/kg), diclofenac (DIC, 60 µmol/kg), piroxicam (PIR, 150µmol/kg) or ketoprofen (KET, 150 µmol/kg) either alone or in the presence of lansoprazole (LAN, 18 and 90 µmol/kg). Each column indicates the mean value obtained from 6-8 animals ± SE (vertical lines). ^aP < 0.05 vs control values; ^cP < 0.05 between the respective values obtained in animals treated with a test NSAID alone.