Lansoprazole prevents experimental gastric injury induced by non-steroidal anti-inflammatory drugs through a reduction of mucosal oxidative damage

Figure 1 H&E-stained sections of rat gastric mucosa. A, treatment with indomethacin 100 µmol/kg, A: severe lesion with necrosis of gastric mucosa; B: several polymorphonuclear cell scan be detected (arrows); C and D: Rats treated with lansoprazole 90 mmol/kg plus indomethacin 100 µmol/kg, C: less severe lesion with lysis of mucosal cells; D: few polymorphonuclear cells can be evidenced (arrows). A and C: original magnification 100; bar = 150 µm. B and D: original magnification 170 x; bar = 60 µm.