Ephrin-B2 is differentially expressed in the intestinal epithelium in Crohn’s disease and contributes to accelerated epithelial wound healing in vitro

Figure 3 Immunohistochemistry of ephrin-B2 from biopsies of normal colon and lesional colon in IBD. (A-C: normal colon; D, F: MC; E: CU.). A-C: ephrin-B2 expression shows a physiologic gradient along the crypt-axis in normal epithelium of the colon, i.e. the maximum staining is found in the luminal, terminally differentiated epithelium of normal colon mucosa. D-F: In MC and CU this gradient is disturbed, i.e. strong ectopic expression in the deep parts of the crypts can be observed. C and F represent cross sections of the deep part of a crypt.