Head-to-head comparison of H2-receptor antagonists and proton pump inhibitors in the treatment of erosive esophagitis: A meta-analysis

Table 6 Healing by grade at 4, 8, 12 wk comparing PPIs with H₂RAs (PP rate)

		4 wk				8 wk				12 wk
		I	II	III	IV	I	II	III	IV	I	II
Number of arms		2	4	3		2	5	3	1
sd PPIs	Pooled data	53/60	128/162	20/54		23/23	166/178	28/47	2/3
	Pooled rate (%)	88.3	79.0	37.0		100.0	93.3	59.6	66.7
sd H2RAs	Pooled data	27/54	65/172	2/41		16/25	101/182	6/34	0/2
	Pooled rate (%)	50.0	37.8	4.9		64.0	55.5	17.6	0
Summary RR		1.760	2.037	5.588		1.502	1.648	2.766	2.525
95%CI		1.329-2.332	1.631-2.545	1.701-18.363		1.107-2.038	1.440-1.885	1.284-5.916	1.046-6.093
No. of arms		2	4	2		2	4	2		1	1
hd PPIs	Pooled data	40/46	88/123	21/30		46/46	104/120	24/30		29/29	42/46
	Pooled rate (%)	87.0	71.5	70.0		100.0	86.7	80.0		100.0	91.3
sd H2RAs	Pooled data	26/50	49/126	3/28		37/49	62/121	6/28		28/32	19/35
	Pooled rate (%)	52.0	38.9	10.7		75.5	51.2	21.4		87.5	54.3
Summary RR		1.665	1.835	6.110		1.300	1.689	3.626		1.111	1.676
95%CI		1.248-2.222	1.436-2.345	2.138-17.459		1.102-1.534	1.400-2.036	1.772-7.418		0.957-1.291	1.222-2.298
Number of arms		2	1	1		2	1	1
ld PPIs	Pooled data	144/175	34/42	9/28		162/175	42/44	15/28
	Pooled rate (%)	82.3	81.0	32.1		92.6	95.5	53.6
sd H2RAs	Pooled data	104/175	15/50	1/22		132/175	27/49	2/21
	Pooled rate (%)	59.4	30.0	4.5		75.4	55.1	9.5
Summary RR		1.384	2.698	7.071		1.227	1.732	5.625
95%CI		1.202-1.592	1.724-4.224	0.967-51.707		1.116-1.349	1.335-2.249	1.440-21.980
Refractory esophagitis
Number of arms			1		1		2	1	2
sd PPIs	Pooled data		62/77		11/22		105/116	13/15	18/29
	Pooled rate (%)		80.5		50.0		90.5	86.7	62.1
sd H2RAs	Pooled data		20/40		1/11		26/61	2/8	0/14
	Pooled rate (%)		50.0		9.1		42.6	25.0	0
Summary RR			1.606		5.500		2.117	3.229	35.881
95%CI			1.158-2.228		0.835-25.337		1.575-2.845	1.034-10.091	0.728-1767.6

sd: standard dose; ld: low dose.