Head-to-head comparison of H2-receptor antagonists and proton pump inhibitors in the treatment of erosive esophagitis: A meta-analysis

Table 5 Healing by grade with standard dose vs high dose of H₂RA at 4, 6, 8, 12 wk (PP rate)

		4-wk		6-wk			8-wk		12-wk
		II	III	I	II	III	II	III	I	II	III
Number of arms		3	3	4	4	4	3	3	4	6	6
Standard dose	Pooled data	84/190	22/105	86/137	102/266	42/180	126/187	37/105	107/129	264/383	119/256
	Pooled rate (%)	44.2	21.0	62.8	38.3	23.3	67.4	35.2	82.9	69.0	46.5
High dose	Pooled data	177/325	60/198	112/157	120/272	60/214	226/323	92/198	122/153	400/532	190/376
	Pooled rate (%)	54.4	30.3	71.3	44.1	28.0	70.0	46.5	79.7	75.2	50.5
Summary RR
95% CI		1.231	1.430	1.136	1.150	1.200	1.039	1.316	0.962	1.032	1.059
		1.020-1.486	0.941-2.202	0.966-1.337	0.939-1.408	0.854-1.686	0.919-1.174	0.977-1.774	0.860-1.076	0.961-1.108	0.913-1.229

PP, per-protocol analysis; No., number; RR, relative risk; 95%CI.