Clinical Research
Copyright ©The Author(s) 2005.
World J Gastroenterol. Jul 14, 2005; 11(26): 4067-4077
Published online Jul 14, 2005. doi: 10.3748/wjg.v11.i26.4067
Table 4 Healing rate of refractory esophagitis at 2, 4, 6, 8, 12 wk comparing PPIs with H2RA
AuthorPPIs
H2RAs
Number of
Healing rate ( ITT )
Number of
Healing rate ( ITT )
DrugDosePatient4 wk8 wk12 wkDrugDosePatient4 wk8 wk12 wk
sd PPIs vs sd H2RA
Feldman (55)Lan30 o.d.6154/61Ran150 b.d.3212/32
Sontag (56)Lan30 o.d.10575/10584/105Ran150 b.d.5428/5416/541
Pooled data16675/105138/1668628/5428/86
Pooled rate (%)71.483.151.932.6
hd PPIs vs hd H2RA
Lundell (57)Ome40 o.d.5132/5135/5146/51Ran300 b.d.478/4718/4722/47