Head-to-head comparison of H2-receptor antagonists and proton pump inhibitors in the treatment of erosive esophagitis: A meta-analysis

doi:10.3748/wjg.v11.i26.4067

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Jul 14, 2005 (publication date) through Aug 7, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Clinical Research

World J Gastroenterol. Jul 14, 2005; 11(26): 4067-4077
Published online Jul 14, 2005. doi: 10.3748/wjg.v11.i26.4067

Table 4 Healing rate of refractory esophagitis at 2, 4, 6, 8, 12 wk comparing PPIs with H₂RA

Author	PPIs						H₂RAs
	Number of			Healing rate ( ITT )			Number of			Healing rate ( ITT )
	Drug	Dose	Patient	4 wk	8 wk	12 wk	Drug	Dose	Patient	4 wk	8 wk	12 wk
sd PPIs vs sd H₂RA
Feldman ⁽⁵⁵⁾	Lan	30 o.d.	61		54/61		Ran	150 b.d.	32		12/32
Sontag ⁽⁵⁶⁾	Lan	30 o.d.	105	75/105	84/105		Ran	150 b.d.	54	28/54	16/54¹
Pooled data			166	75/105	138/166				86	28/54	28/86
Pooled rate (%)				71.4	83.1					51.9	32.6
hd PPIs vs hd H₂RA
Lundell ⁽⁵⁷⁾	Ome	40 o.d.	51	32/51	35/51	46/51	Ran	300 b.d.	47	8/47	18/47	22/47

Ome: omeprazole; Lan: lansoprazole; Ran: ranitidine; o.d.: once daily in the morning; b.d.: twice daily; h.d.: high dose; sd: standard dose. This study did not report cumulative healing rate at 8 wk. All patients’ endpoint was at 8 wk. The decreased healing rate at 8 wk for ranitidine group may be due to subsequent relapse of esophagitis.

Citation: Wang WH, Huang JQ, Zheng GF, Xia HHX, Wong WM, Lam SK, Wong BCY. Head-to-head comparison of H₂-receptor antagonists and proton pump inhibitors in the treatment of erosive esophagitis: A meta-analysis. World J Gastroenterol 2005; 11(26): 4067-4077
URL: https://www.wjgnet.com/1007-9327/full/v11/i26/4067.htm
DOI: https://dx.doi.org/10.3748/wjg.v11.i26.4067