Head-to-head comparison of H2-receptor antagonists and proton pump inhibitors in the treatment of erosive esophagitis: A meta-analysis

Table 3 Healing rate (ITT) of esophagitis at 2, 4, 8 wk comparing PPIs with omeprazole

	Other PPIs			Omeprazole
	2-wk	4-wk	8-wk	2-wk	4-wk	8-wk
sd PPIs vs sd Omeprazole
Number of arms	1	12	12	1	12	12
Pooled data	264/421	2 615/3 412	3 050/3 411	257/431	2 229/3 217	2 719/3 216
Pooled healing rate (%)	62.7	76.6	89.4	59.6	69.3	84.5
Summary RR				1.052	1.044	1.061
95%CI				0.945–1.171	0.983-1.109	0.979-1.055
ld PPIs vs sd Omeprazole
Number of arms		2	2		2	2
Pooled data		590/822	724/822		551/811	707/811
Pooled healing rate (%)		71.8	88.1		67.9	87.2
Summary RR					1.026 0.981
95%CI					0.904-1.164	0.870-1.105
sd PPIs vs hd Omeprazole
Number of arms		2	1		2	1
Pooled data		310/440	284/337		302/434	282/332
Pooled healing rate (%)		70.5	84.3		69.6	84.9
Summary RR					1.031	0.985
95%CI					0.937-1.015	0.883-1.099

hd: high dose; sd: standard dose; ld: low dose; ITT, intention-to-treat analysis; No., number; RR, relative risk; 95% CI, 95% CIs.