Head-to-head comparison of H2-receptor antagonists and proton pump inhibitors in the treatment of erosive esophagitis: A meta-analysis

Table 2 Healing rate of esophagitis by ITT at 2, 3, 4, 8, 12 wk comparing proton pump inhibitors (PPIs) with H₂RA

	PPIs				H2RA
	2-wk	4-wk	8-wk	12-wk	2-wk	4-wk	8-wk	12-wk
sd PPIs vs sd H2RA
Number of arms	2	13	12		2	13	12
Pooled data	116/183	577/824	640/783		60/163	271/713	350/673
Pooled healing rate (%)	63.4	70.0	81.7		36.8	38.0	52.0
Summary RR	1.759	1.832	1.586
95%CI	1.398-2.213	1.622-2.070	1.438-1.749
hd PPIs vs sd H2RA
Number of arms		4	4	1		4	4	1
Pooled data		150/204	175/201	72/80		79/211	106/207	49/81
Pooled healing rate (%)		73.5	87.1	90.0		37.4	51.2	60.5
Summary RR		1.722	1.623	1.488
95%CI		1.464-2.027	1.417-1.859	1.230-1.800
sd PPIs vs hd H2RA
Number of arms		2	2		2	2
Pooled data		152/235	208/235		87/234	155/234
Pooled healing rate (%)		64.7	88.5		37.2	66.2
Summary RR		1.744	1.336
95%CI		1.442-2.110	1.206-1.481
ld PPIs vs sd H2RA
Number of arms		3	3		3	3
Pooled data		187/279	219/279		120/276	161/276
Pooled healing rate (%)		67.0	78.5		43.5	58.3
Summary RR		1.605	1.374
95%CI		1.156-2.229	1.081-1.744

hd: high dose; sd: standard dose; ld: low dose; ITT, intention-to-treat analysis; No., number; RR, relative risk; 95% CI, 95% CIs.