Head-to-head comparison of H2-receptor antagonists and proton pump inhibitors in the treatment of erosive esophagitis: A meta-analysis

Table 1 Healing rate of esophagitis by ITT with standard dose vs high dose of H₂RA at 3, 4, 6, 8, 12 wk

		3-wk	4-wk	6-wk	8-wk	12-wk
Number of comparisons		1	5	9	5	12
High dose	Pooled data	29/169	297/669	607/1 294	413/669	1 142/1 729
	Pooled healing rate (%)	17.2	44.4	46.9	61.7	66.0
Standard dose	Pooled data	33/168	198/573	584/1 361	309/573	920/1 520
	Pooled healing rate (%)	19.6	34.6	42.9	53.9	60.5
Summary RR		0.874	1.281	1.096	1.165	1.084
95% CI		0.557-1.371	1.036-1.583	0.930-1.293	1.020-1.329	1.019-1.152

ITT, intention-to-treat analysis; No, number; RR, relative risk; 95%CI.