Herbal medicine Ninjinyoeito ameliorates ribavirin-induced anemia in chronic hepatitis C: A randomized controlled trial

Table 5 Comparison of NYT and other drugs which were reported to be effective for RBV-induced anemia

	Action	Mechanisms	Indication for anemia in health	Form	Adverse reactions	Daily cost
			insurance system of Japan			(yen)
NYT	Promotion of erythropoiesis,	Activation of immature	Anemia in	Granule	Abdominal discomfort	227.7
	protection of erythrocytic	erythroid cells,	general,		(frequency unknown)
	membrane, improvement of	antioxidant effect
	erythrocytic deformability
EPA	Increase in erythrocyte	Increase in EPA content in	None	Capsule	Jaundice, gynecomastia	353.4
	deformability	erythrocytic membrane			(frequency unknown),
		phospholipids			hemorrhagic tendency,
					liver injury (< 0.1%)
EPO	Increase in erythropoiesis	Stimulation of stem cell	Renal anemia	Vial for	Thromboembolism,	1643
		differentiation to		injection	cerebral hemorrhage,	(750 IU)
		erythroid cells			shock (frequency unknown),
					high blood pressure, liver
					injury (0.1-< 5%)