Cyclooxygenase-2 promotes angiogenesis by increasing vascular endothelial growth factor and predicts prognosis in gallbladder carcinoma

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Jun 28, 2005 (publication date) through Jul 29, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Clinical Research

World J Gastroenterol. Jun 28, 2005; 11(24): 3724-3728
Published online Jun 28, 2005. doi: 10.3748/wjg.v11.i24.3724

Table 1 COX-2, VEGF, and MVC status in relation to clinicopathological characteristics of patients.

Pathological characteristics	n	Positive VEGF (%)	Positive COX-2 (%)	MVC
Sex
Male	28	17 (60.7)	21 (75.0)	56±12
Female	36	18 (50.0)^a	25 (69.4)^a	58±16^a
Age (yr)
≥60	30	16 (53.3)	22 (73.3)	54±13
<60	34	19 (55.9)^a	24 (70.6)^a	60±15^a
Clinical stage
S₁, S₂, S₃	20	10 (50.0)	10 (50.0)	49±15
S₄, S₅	44	25 (56.8)^a	36 (81.8)^b	64±12^b
Degree of differentiation
Well differentiated	21	7 (33.3)	12 (57.1)	50±14
Moderately and poorly	43	28 (65.1)^c	34 (79.1)^a	61±13^b
differentiated
Lymph node metastasis
Positive	40	28 (70.0)	35 (87.5)	65±12
Negative	24	7 (29.2)^b	11 (45.8)^b	45±7^b

^aP<0.05,

^bP<0.01,

^cP<0.05 vs control.

Citation: Zhi YH, Liu RS, Song MM, Tian Y, Long J, Tu W, Guo RX. Cyclooxygenase-2 promotes angiogenesis by increasing vascular endothelial growth factor and predicts prognosis in gallbladder carcinoma. World J Gastroenterol 2005; 11(24): 3724-3728
URL: https://www.wjgnet.com/1007-9327/full/v11/i24/3724.htm
DOI: https://dx.doi.org/10.3748/wjg.v11.i24.3724