Activation of JAK-STAT pathway is required for platelet-derived growth factor-induced proliferation of pancreatic stellate cells

Figure 5 Activation of Src and JAK2 is required for PDGF-induced proliferation and serum-starved PSCs were treated with PDGF-BB (at 25 ng/mL) in the presence or absence of AG490 (at 10 or 25 μmol/L) or PP1 (at 1 or 2. 5 μmol/L). After 24-h incubation, DNA synthesis was assessed by BrdU incorporation ELISA. Data are shown as mean±SD (n = 6). ^bP<0.01 versus PDGF-BB only. Con: control (serum-free medium only), A: optical density.