Cholecystokinin octapeptide improves cardiac function by activating cholecystokinin octapeptide receptor in endotoxic shock rats

Table 1 Comparison of the cardiac functions after administration of sCCK-8 and proglumide (mean±SD; n = 6).

	CCK(mg)				Proglumide +CCK4.0 mg /kg
	Pre-administration	0.4 mg /kg	4.0 mg/ kg	40 mg /kg
HR/bmp	391±22	441±27b	353±18b	340±21b	427±36bd
MAP/kPa	14.07±1.68	16.96±1.79b	17.29±1.63b	17.46±1.08b	15.96±1.38bd
LVP/kPa	16.48±2.56	18.21±1.69b	19.46±2.57b	19.83±2.91b	17.36±0.66bd
LVdp/dtmax(kPa.S)-1	634.43±32.88	768.85±31.28b	831.46±22.57b	914.52±35.95b	748.18±19.29b.d
LVdp/dtmin(kPa.S) -1	429.82±18.95	565.04±27.71b	606.08±31.32b	639.15±30.23b	512.12±14.39bd

^bP<0.01 vs preadministration;

^dP<0.01 vs medium dose of sCCK-8 group.