Oncogenic role of clusterin overexpression in multistage colorectal tumorigenesis and progression

Figure 1 Expression of clusterin in different pathological loci of one Dukes C colorectal carcinoma with matched lymph node metastasis. Strong cytoplasmic staining of clusterin was observed in primary carcinoma in the mucosa layer of the bowel wall, while its adjacent normal mucosa showed a weak positivity (A). Strong cytoplasmic staining of clusterin was also observed in carcinomas in muscularis propria (B), and serosa layer (C) and its matched lymph node metastasis (D) in the same primary carcinoma (original magnification ×100).