Helicobacter pylori promote gastric cancer cells invasion through a NF-kB and COX-2-mediated pathway

Figure 5 Immunohistochemical detection of COX-2, MMP-9, and VEGF in gastric cancer tissues. The serial sections of gastric cancer surgical specimens were stained with anti-COX-2 (A and B), anti-MMP-9 (C and D), and anti-VEGF (E and F) antibodies. Sections were counterstained with hematoxylin. The immunoreactivities of COX-2, MMP-9 and VEGF are predominantly detected in the cytoplasm of the tumor cell. Tissues in A, C, and E are from H pylori-positive patients, whereas, sections in B, D, and F are from H pylori-negative individuals. (Magnification: A-F: 400×).