Gene expression in Barrett’s esophagus and reflux esophagitis induced by gastroduodenoesophageal reflux in rats

Table 3 Functional classification of genes expressed differently between Barrett’s esophagus and esophagitis epithelia.

Functional classification	n	Up-regulated	Down-regulated
Oncogenes and tumor suppressor genes	14	12	2
Ion channel and transporters	30	16	14
Cell cycle proteins	21	18	3
Extra-pressure reaction proteins	20	18	2
Cell regulatory proteins	13	9	4
Cell apoptosis related proteins	14	10	4
DNA synthesis, repair and recombinant factors	25	17	8
DNA binding, transcription factors	30	22	8
Cell receptors	33	27	8
Immunity-related proteins	29	17	12
Cell signal transduction proteins	40	27	13
Metabolism related proteins	31	21	10
Total	300	214	86