Molecular mechanisms of denbinobin-induced anti-tumorigenesis effect in colon cancer cells

Figure 6 Growth of COLO 205 tumor xenografts in nude mice was suppressed by denbinobin treatment. Athymic nude mice injected with COLO 205 cells into subcutaneous tissue of inter-scapular area. Once tumor volume reached approximately 200 mm³, the animal received treatment of 50 mg/kg denbinobin or DMSO intraperitoneally thrice per week for 4 wk. (A) Average tumor volume (B) body weight of DMSO-treated (n = 5, filled circles) vs denbinobin-treated (n = 4, open circles) nude mice. Samples were analyzed in each group, and values represent the mean±SE. Comparisons were subjected to linear regression method in (A) and showed significant difference between DMSO vs denbinobin treatment group.