Clinicopathological significance of loss of heterozygosity and microsatellite instability in hepatocellular carcinoma in China

Table 2 Clinicopathologic correlation of LOH in HCC.

Parameter	Locus	LOH/informative cases		P
HBsAg		Positive	Negative
	D1S2893	17/31	1/13	0.004
	D1S507	13/21	1/16	0.001
	D4S406	20/26	2/16	0.001
	D8S277	16/22	2/16	0.001
	D8S261	10/27	13/16	0.005
	D8S298	11/29	12/15	0.008
	D8S1733	7/24	10/14	0.011
	D16S512	10/31	10/14	0.014
	D16S515	5/27	7/9	0.001
	D17S831	19/21	6/16	0.001
	D17S938	19/25	2/14	0.001
	D17S926	13/27	8/9	0.032
AFP (mg/L)		<20	≥20
	D1S507	3/17	21/29	0.001
	D16S413	9/12	7/24	0.009
Liver cirrhosis		Present	Absent
	D16S534	20/34	1/9	0.011
	D16S3091	24/33	1/9	0.001
	D16S422	22/34	1/8	0.008
	D17S849	21/31	1/8	0.005
	D17S831	24/39	1/8	0.011
	D17S799	20/35	1/7	0.038
Tumor size		≤3 cm	>3 cm
	D8S298	2/9	21/35	0.043
	D8S1771	0/9	21/31	0.001
	D16S498	4/12	19/24	0.007
	D17S926	3/11	18/25	0.012
Histological grade		Well	Moderate and poor
	D4S426	2/11	23/30	0.002
	D4S1615	2/12	14/26	0.04
	D4S1652	2/11	17/28	0.031
	D16S498	2/18	21/29	0.001
	D17S926	4/13	17/23	0.012
Tumor capsule		Absent or not intact	Intact
	D8S1721	20/28	1/12	0.001
Intrahepatic metastasis		Not observed	Observed
	D1S468	8/10	5/25	0.001
	D4S2921	2/21	21/23	0.023
	D8S298	2/10	21/34	0.02
	D8S1771	2/9	19/31	0.039
	D17S926	1/11	20/25	0.001
	D17S786	0/10	15/29	0.004