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©2005 Baishideng Publishing Group Co.
World J Gastroenterol. Jan 14, 2005; 11(2): 289-292
Published online Jan 14, 2005. doi: 10.3748/wjg.v11.i2.289
Published online Jan 14, 2005. doi: 10.3748/wjg.v11.i2.289
Risk factor | Variable | HCC case | Control | Crude | Adjusted | P |
n (%) | n (%) | OR (95% CI) | OR (95% CI)1 | |||
p53 Arg72Pro | Arg | 563 (55.5) | 646 (59.7) | 1 | ||
Pro | 451 (44.5) | 436 (40.3) | 1.19 (1.00-1.41) | 0.05 | ||
Arg/Arg | 145 (28.6) | 188 (34.8) | 1 | 1 | ||
Arg/Pro | 273 (53.8) | 270 (49.9) | 1.31 (1.00-1.73) | 1.21 (0.82-1.78) | 0.34 | |
Pro/Pro | 89 (17.6) | 83 (15.3) | 1.39 (0.96-2.01) | 1.79 (1.06-3.01) | 0.03 | |
Sex | Female | 73 (14.4) | 278 (51.4) | 1 | 1 | |
Male | 434 (85.6) | 263 (48.6) | 6.28 (4.66-8.48) | 4.97 (3.28-7.52) | <0.001 | |
Cigarette smoking | No | 288 (56.8) | 437 (80.8) | 1 | 1 | |
Yes | 219 (43.2) | 104 (19.2) | 3.20 (2.42-4.21) | 1.90 (1.19-3.02) | <0.01 | |
Alcohol drinking | No | 304 (60.0) | 446 (82.4) | 1 | 1 | |
Yes | 203 (40.0) | 95 (17.6) | 3.13 (2.36-4.16) | 1.20 (0.75-1.93) | 0.44 | |
HBsAg | Negative | 137 (27.0) | 445 (82.3) | 1 | 1 | |
Positive | 370 (73.0) | 96 (17.7) | 12.52 (9.32-16.82) | 16.83 (11.53-24.56) | <0.001 | |
Anti-HCV | Negative | 469 (92.5) | 527 (97.4) | 1 | 1 | |
Positive | 38 (7.5) | 14 (2.6) | 3.05 (1.63-5.69) | 7.29 (3.17-16.80) | <0.001 | |
Family history2 | No | 433 (85.4) | 532 (98.3) | 1 | 1 | |
Yes | 74 (14.6) | 9 (1.7) | 10.07 (5.00-20.33) | 9.47 (3.92-22.90) | <0.001 |
- Citation: Zhu ZZ, Cong WM, Liu SF, Dong H, Zhu GS, Wu MC. Homozygosity for Pro of p53 Arg72Pro as a potential risk factor for hepatocellular carcinoma in Chinese population. World J Gastroenterol 2005; 11(2): 289-292
- URL: https://www.wjgnet.com/1007-9327/full/v11/i2/289.htm
- DOI: https://dx.doi.org/10.3748/wjg.v11.i2.289