Clinical usefulness of biochemical markers of liver fibrosis in patients with nonalcoholic fatty liver disease

Table 5 Diagnostic accuracy of the markers of liver fibrosis for severe fibrosis.

	ROC analysis		Cutoff value	Accuracy
	AUC (95% CI)	P value		Se (%)	Sp (%)	PPV (%)	NPV (%)
(a) Type IV collagen 7S	0.817 (0.736-0.897)	0.000	≥5.0 ng/mL	81.3	71.4	68.4	83.6
(b) Hyaluronic acid	0.797 (0.652-0.845)	0.000	≥50 ng/mL	68.8	82.8	75.0	77.9
Combination of Markers			a≥5.0 ng/mL	95.8	62.5	65.7	95.2
			or b≥50 ng/mL
			a≥5.0 ng/mL	54.2	92.2	83.9	72.8
			and b≥50 ng/mL

Abbreviations: ROC, receiver operating characteristic; AUC, area under the ROC curve; CI, confidence interval; Se, sensitivity; Sp, specificity; PPV, positive predictive value; NPV, negative predictive value.