Clinical usefulness of biochemical markers of liver fibrosis in patients with nonalcoholic fatty liver disease

Table 4 Diagnostic accuracy of the markers of liver fibrosis for NASH.

	ROC analysis		Cutoff value	Accuracy
	AUC (95% CI)	P value		Se (%)	Sp (%)	PPV (%)	NPV (%)
(a) Type IV collagen 7S	0.828 (0.754-0.902)	0.000	≥5.0 ng/mL	70.0	81.0	86.0	61.8
(b) Hyaluronic acid	0.797 (0.716-0.879)	0.000	≥43 ng/mL	65.7	90.5	92.0	61.3
Combination of Markers			a≥5.0 ng/mL	87.1	73.8	84.7	77.5
			or b≥43 ng/mL
			a≥5.0 ng/mL	48.6	97.6	97.1	53.2
			and b≥43 ng/mL

Abbreviations: ROC, receiver operating characteristic; AUC, area under the ROC curve; CI, confidence interval; Se, sensitivity; Sp, specificity; PPV, positive predictive value; NPV, negative predictive value.