Clinical usefulness of biochemical markers of liver fibrosis in patients with nonalcoholic fatty liver disease

Table 2 Comparison between patients with fatty liver and with NASH (mean±SD).

	Fatty liver alone	NASH	P value
Number	42	70
Age (yr)	45.2±13.6	53.8±14.4	0.002
Gender (female)	22 (52.4%)	54 (77.1%)	0.012
BMI	28.2±4.9	29.6±5.2	NS
Diabetes mellitus (%)	8 (19.0%)	26 (37.1%)	0.044
Platelet count (±104/mL)	23.8±4.8	21.1±6.8	0.036
Prothrombin time (%)	98.5±11.1	91.6±13.6	0.009
Albumin (g/dL)	4.4±0.3	4.3±0.4	0.01 7
AST (IU/L)	56.7±30.8	87.5±48.1	<0.001
ALT (IU/L)	110.1±68.2	117.1±65.1	NS
AST/ALT ratio	0.56±0.2	0.82±0.4	<0.001
GGT (IU/L)	124.9±96.6	106.2±129.3	NS
IgG (mg/dL)	1 377.1±366.7	1 526.9±423.3	NS
IgA (mg/dL)	313.1±191.3	356.9±134.1	NS
IgM (mg/dL)	124.2±47.9	162.8±82.4	0.004
Type IV collagen 7S (ng/mL)	4.1±0.9	6.0±2.0	<0.001
Hyaluronic acid (ng/mL)	29.0±20.0	103.4±116.8	<0.001
Fasting glucose (mg/dL)	107.8±34.4	120.2±51.8	NS
HbA1c (%)	5.4±1.0	6.2±1.7	0.005
Ferritin (ng/mL)	151.7±107.0	351.5±455.7	0.001
FFA (mEq/L)	0.6±0.2	0.7±0.3	0.022
HOMA-R	5.1±6.3	6.0±6.6	NS