Clinical significance of the expression of isoform 165 vascular endothelial growth factor mRNA in noncancerous liver remnants of patients with hepatocellular carcinoma

Table 5 Correlation between the clinical features of recurrent hepatocellular carcinoma and the expression of VEGF₁₆₅ mRNA in primary lesions.

Clinical features	VEGF165 mRNA		P
	high (n = 14)	low (n = 2)
Extent of recurrent tumors:
Extrahepatic metastasis (number, %)	8(57.1)	1(50.0)	NS
Multiple recurrent tumors (number, %)	10(71.4)	1(50.0)	0.043
Involvement over two-segments (number, %)	10(71.4)	1(50.0)	0.043
Survival after recurrence (median mo)	4.4	11	0.048
Treatment for recurrent tumors
Surgery (number)	0	0	NS
Non-surgical treatment1 (number, %)	8(57.1)	1(50.0)	NS
No treatment (number, %)	6(42.9)	1(50.0)	NS

Notes: NS: no statistical significance; non-surgical treatments1: treatment with transcatheter arterial chemoembolization or/and percutaneous ethanol injection. High VEGF₁₆₅ mRNA: ≥0.500; low VEGF₁₆₅ mRNA: <0.500.