Cytotoxic effect of a non-peptidic small molecular inhibitor of the p53-HDM2 interaction on tumor cells

Figure 4 Syl-155-induced apoptosis of HT1080 cells. Time course analysis for the occurrence of apoptosis induced by syl-155. HT1080 cells were treated with 10 μg/mL syl-155 for 0-72 h, stained with PI, and analyzed by flow cytometry to quantitate cells with a subdiploid DNA content. The data were expressed as mean±SD, ^aP<0.05 vs DMSO group, ^cP<0.05 vs DMSO group, ^eP<0.05 vs DMSO group.