Sulindac induces apoptosis and protects against colon carcinoma in mice

doi:10.3748/wjg.v11.i18.2822

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May 14, 2005 (publication date) through Nov 30, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. May 14, 2005; 11(18): 2822-2826
Published online May 14, 2005. doi: 10.3748/wjg.v11.i18.2822

Table 5 The density comparison of proliferation and apoptosis with moderate dysplasia in model-agent group, sulindac-preventative group and sulindac-curative group (number/mm²).

Group	n	Proliferative cell density (mean±SD)	Apoptotic cell density (mean±SD)	Ratio (apoptosis/roliferation)
Model-agent	9	114.7±31.7	57.1±17.3^a	0.50
Preventive	7	118.9±21.4	107.8±35.0	0.91
Curative	3	133.0±27.5	62.7±20.3^a	0.47

n = number of mice.

^aP<0.05 vs preventive group the cell density of proliferation and apoptosis in the model-agent group and sulindac-curative group were higher than in the sulindac-preventative group resulting in a statistically significant difference.

Citation: Sun BC, Zhao XL, Zhang SW, Liu YX, Wang L, Wang X. Sulindac induces apoptosis and protects against colon carcinoma in mice. World J Gastroenterol 2005; 11(18): 2822-2826
URL: https://www.wjgnet.com/1007-9327/full/v11/i18/2822.htm
DOI: https://dx.doi.org/10.3748/wjg.v11.i18.2822