Genetic association of cytokines polymorphisms with autoimmune hepatitis and primary biliary cirrhosis in the Chinese

Table 3 Genotype distributions of cytokines in AIH, PBC patients vs controls.

Cytokine	Genotype	Controls (%)	AIH (%)	P	PBC (%)	P
IL-1B	+3953
	1,1	155 (96.9)	61 (98.4)	0.53	75 (97.4)	0.82
	1,2	4 (2.5)	1 (1.6)	0.69	2 (2.6)	0.96
	2,2	1 (0.0)	0 (0)	0.53	0 (0)	0.46
IL-1RN	Intron 2
	1,1	127 (79.4)	51 (82.3)	0.63	70 (90.9)	0.026
	1,2	30 (17.5)	10 (16.1)	0.64	5 (6.5)	0.013
	2,2	3 (1.9)	1 (1.6)	0.90	2 (2.6)	0.75
	others	0 (0)	0 (0)	-	0 (0)	-
IL-6	-174 G/C1
	GG	160 (100)	62 (100)	-	73 (94.8)	0.0036
	GC	0 (0)	0 (0)	-	4 (5.2)	0.0036
	CC	0 (0)	0 (0)	-	0 (0)	-
IL-10	-1082G/A
	AA	144 (90.0)	54 (87.1)	0.53	64 (83.1)	0.13
	GA	16 (10.0)	8 (12.9)	0.53	13 (16.9)	0.13
	GG	0 (0)	0 (0)	-	0 (0)	-
	-819T/C
	CC	13 (8.1)	7 (11.3)	0.46	7 (9.1)	0.80
	CT	72 (45.0)	27 (43.6)	0.84	41 (53.3)	0.23
	TT	75 (46.9)	28 (45.2)	0.81	29 (37.7)	0.18
	-592A/C
	CC	16 (10.0)	10 (16.1)	0.2	11 (14.3)	0.33
	CA	83 (51.9)	32 (51.6)	0.97	41 (53.3)	0.84
	AA	61 (38.1)	20 (32.3)	0.41	25 (32.5)	0.4

¹The frequency of IL-6 -174C allele in PBC group vs control, P = 0.0038.