Blood platelet and monocyte activations and relation to stages of liver cirrhosis

Table 1 Blood plt, monocyte serum and cytometric parameters in clinical stages of LC according to Child-Pugh classification.

	Healthy	Cirrhosis hepatitis stage (Child–Pugh)
		B	C
Blood plt
Blood plt (1×103/mL)	219±25	124±77a	115±66a
sP-selectin (pg/mL)	133±70	74±42a	69±35a
PF4 (IU/mL)	36±7	30±9	26±16
bTG (IU/mL)	128±45	137±40	101±62
CD62P (%)	6±1.8	10±4a	9.3±3a
MIF CD62	0.47±0.08	0.66±0.2a	0.66±0.2a
CD63 (%)	0.7±0.3	2.2±1.5	1.5±0.9
MIF CD63	0.3±0.04	0.4±0.09a	0.4±0.07a
Monocyte
Monocyte (%)	5.7±3.1	6.8±3.3	7.0±2.9
MCP-1 (pg/mL)	218±129	150±93	153±81
MIF CD14	26±2	27±7	26±4
CD16 (%)	2.9±1.6	7.9±7.8a	8.1±5.2a
MIF CD16	1.5±0.5	1.9±1.1	2.9±1.5a
CD11b (%)	100±0.1	99.5±0.8	99.5±2.0a
MIF CD11	17.4±5.8	18.5±4.8	21.2±5.9a
Aggregates
Plt–monocytes (%)	13.5±4.0	10.7±5.6	13.6±16.8
MIF CD45 on plt–monocyte aggregates	11.8±3.6	11.6±3.5	15.1±4.5

^aP<0.05 vs Healthy statistical significance in healthy subjects, Mann–Whitney U-test. MIF-medial intensity of fluorescence.