Phase I/II enzyme gene polymorphisms and esophageal cancer risk: A meta-analysis of the literature

Table 4 Results of meta-regression analysis and Egger’s test for publication bias.

	Number of studies	Egger’s test Forpublicationbias1 P	Results of meta-regression test
			Asian Yes/no Coefficient3	Chinese Yes/no Coefficient3	Publication Year Coefficient3	Design 1 or 22 Coefficient3	Matching Yes/no Coefficient3
CYP1A1 Ile-Val	8	0.96	-0.1	0.19	0.11	-0.2	-0.22
CYP1A1 MspI	5	0.96	-0.42	-0.67	-0.9	0.01	-0.01
CYP2E RsaI	5	0.32	1	-0.89	0.76	1.3	-0.13
GSTM1	12	0.04	0.06	0.21	0.25	-0.34	-0.16
GSTT1	6	0.11	0.34	0.34	-0.16	0.37	0.16
GSTP1	7	0.99	-1.254	-0.07	0.88	0.4	0.02

¹P-value of Egger’s test for publication bias. ²Study design: 1: population-based case-control study, 2: hospital-based case-control study.

³Coefficient in the meta-regression analysis indicates the summary OR change in the value for that factor. For example, the OR for studies examining CYP1A1 Ile-Val polymorphism only among Asian population is the value of (summary OR-0.1). ⁴Indicates statistical significance at the level of P<0.10.