Phase I/II enzyme gene polymorphisms and esophageal cancer risk: A meta-analysis of the literature

Table 1 Summary of studies included in the analysis of CYP1A1, CYP2E1, GASTM1, GSTT1 and GSTP1.

Study	Yr	Study design	Cases Mean age	Controls Mean age	Cases Man (%)	Controls Man (%)	Polymorphisms	Result	Adjusted factors	Reference
Hori H	1997	2	NA	NA	78 (83)	NA	CYP1A1, MspI	NS		42
							CYP1A1, IIe-Val	NS
							GSTM1	NS
							CYP2E1, Rsal	NS
Nimura Y	1997	1	NA	NA	67 (75)	76 (55)	CYP1A1, IIe-Val	S		43
							GSTM1	NS
Morita S	1997	2	62.2	50.5	45 (85)	112 (85)	CYP1A1, IIe-Val	NS		44
							CYP2E1, Rsal	NS
							GSTM1	NS
Morita S	1998	2	62.1	49.8	56 (85)	102 (62)	GSTP1	S		45
Lin DX	1998	NA	55.5	53.3	27 (60)	23 (50)	CYP2E1, Rsal	S	Adjusted by age and sex	36
							CYP2E1,Dral	NS
							GSTM1	NS
							GSTT1	NS
							GSTP1	NS
Van Lieshout EM	1999	2	NA	52	27 (79)	98 (40)	CYP1A1, MspI	S	46
							CYP1A1, IIe-Val	NS
							GSTM1	NS
							GSTT1	NS
							GSTP1	S
Shao G	2000	2	55	53	74 (69)	80 (72)	CYP1A1, IIe-Val	NS		47
							GSTM1	S
Lee JM	2000	2	NA	NA	82 (91)	228 (89)	GSTP1	NS	Adjusted by potential factors	48
Tan W	2000	2	54.5	53.6	99 (66)	99 (66)	CYP2E1, Rsal	S	Adjusted by age, sex and smoking	49
							GSTM1	S
							GSTT1	NS
							GSTP1	NS
Wu M-T	2002	1	60.6	61.2	133 (91)	298 (92)	CYP1A1, MspI	NS	Adjusted by age, sex, smoking and alcohol, etc.	50
							CYP1A1, IIe-Val	S
Gao CM	2002	2	NA	NA	55 (59)	131 (66)	CYP2E1, Rsal	NS	Adjusted by age, sex and potential factors	51
Yokoyama A	2002	2	61.7	58.8	234 (100)	634 (100)	GSTM1	NS		52
Gao CM	2002	2	NA	NA	78 (55)	149 (67)	GSTM1	S	Adjusted by age and sex	53
							GSTT1	NS
Wang LD	2003	2	NA	NA	32 (53)	NA	CYP1A1, MspI	NS		54
							CYP1A1, IIe-Val	NS
							GSTM1	NS
							GSTT1	NS
							GSTP1	NS
Casson AG	2003	2	NA	NA	38 (84)	38 (84)	CYP1A1, MspI	NS	Adjusted by age, sex and smoking	55
							CYP1A1, IIe-Val	NS
							GSTM1	NS
							GSTT1	NS
							GSTP1	S
Wang AH	2004	1	NA	NA	97 (76)	78 (77)	CYP1A1, IIe-Val	S		37
							GSTM1	S

1: Population-based case-control study, 2: hospital-based case-control study. NA, not available; NS, not significant (P>0.05); S, significant (P<0.05).