Combined effects of Cantide and chemotherapeutic drugs on inhibition of tumor cells’ growth in vitro and in vivo

Figure 1 HepG2 cells’ growth inhibited by Cantide, DDP(A), 5-FU(B) and ADM(C) only and at the indicated combinations on HepG2 cells. The dots represent the concentrations of chemotherapeutic drugs as 0 on the dose-response curves which means treatments with Cantide only. The cells were treated with Cantide complexed to Lipofectin for 6 h at 37 °C. The medium was then replaced with media containing various concentrations of DDP, 5-FU and ADM. After 72 h of incubation, MTT assay was performed. Absorbance at 490 nm was normalized to the control, untreated cells to determine cell viability. Each value represents the mean±SD from triplicate determination.