No association of the matrix metalloproteinase 1 promoter polymorphism with susceptibility to esophageal squamous cell carcinoma and gastric cardiac adenocarcinoma in northern China

Table 3 Influence of the MMP-1 SNP on lymphatic metastasis in ESCC and GCA¹.

Groups	LM negative cases (%)	LM positive cases (%)	aOR (95%CI)2
ESCC
1G/1G	12 (16.7)	6 (10.2)	1.0 (ref.)
2G/2G	31 (43.0)	29 (49.2)	1.72 (0.58-5.33)
1G/2G+2G/2G	60 (83.3)	53 (89.8)	1.73 (0.60-4.97)
GCA
1G/1G	7 (14.6)	2 ( 4.4)	1.0 (ref.)
2G/2G	25 (52.1)	28 (60.9)	3.80 (0.71-20.41)
1G/2G+2G/2G	41 (85.4)	44 (95.6)	3.66 (0.71-18.87)

ESCC: esophageal squamous cell carcinoma; GCA: gastric cardiac adenocarcinoma; LM: lymphatic metastasis, ¹all of the 131 ESCC (53 LM positive and 60 negative) and 96 GCA patients (46 LM positive and 48 negative) with available related data were considered;

²the age and sex adjusted odds ratio of the 2G/2G and 2G/1G+1G/1G genotype against the 1G/1G genotype.