No association of the matrix metalloproteinase 1 promoter polymorphism with susceptibility to esophageal squamous cell carcinoma and gastric cardiac adenocarcinoma in northern China

doi:10.3748/wjg.v11.i16.2385

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Esophageal Cancer

World J Gastroenterol. Apr 28, 2005; 11(16): 2385-2389
Published online Apr 28, 2005. doi: 10.3748/wjg.v11.i16.2385

Table 2 Association analysis of the MMP1 SNP with the risk of ESCC and GCA development.

	1G/1G	2G/2G	2G/1G+2G/2G	aOR (95%CI)³	aOR (95%CI)⁴
Overall
Normal	51 (14.9)	194 (55.4)	299 (85.4)
ESCC	28 (12.0)	130 (55.6)	206 (88.0)	1.28 (0.78-2.09)	1.23 (0.38-2.05)
GCA	20 (10.9)	112 (61.2)	163 (89.1)	1.39 (0.80-2.41)	1.34 (0.74-2.40)
Non-smoker¹
Normal	25 (15.6)	89 (55.6)	135 (84.4)
ESCC	10 (10.6)	58 (61.7)	84 (89.4)	1.55 (0.65-3.46)	1.54 (0.68-3.48)
GCA	10 (13.5)	40 (54.1)	64 (86.5)	1.12 (0.49-2.58)	1.20 (0.38-3.82)
Smoker
Normal	18 (15.0)	64 (53.3)	102 (85.0)
ESCC	14 (14.6)	46 (47.9)	82 (85.4)	1.03 (0.48-2.19)	0.93 (0.42-2.06)
GCA	8 ( 8.7)	59 (64.1)	84 (91.3)	1.80 (0.74-4.37)	1.36 (0.46-4.05)
Negative family history²
ESCC	16 (12.5)	73 (57.0)	112 (87.5)	1.19 (0.65-2.18)	1.18 (0.63-2.20)
GCA	7 ( 7.3)	54 (56.2)	89 (92.7)	1.19 (0.56-2.51)	0.42 (0.16-1.04)
Positive family history³
ESCC	8 (14.3)	29 (51.8)	48 (85.7)	1.02 (0.46-2.29)	0.95 (0.41-2.21)
GCA	10 (16.1)	38 (61.3)	52 (83.9)	0.95 (0.59-1.53)	0.72 (0.31-1.70)

ESCC: esophageal squamous cell carcinoma; GCA: gastric cardiac adenocarcinoma; ^1,2information of smoking status and family history was available from a subset of subjects; ^3,4the age and sex adjusted odds ratio of the 2G/2G (c) and 1G/2G+2G/2G genotype (d) against the 1G/1G genotype.

Citation: Jin X, Kuang G, Wei LZ, Li Y, Wang R, Guo W, Wang N, Fang SM, Wen DG, Chen ZF, Zhang JH. No association of the matrix metalloproteinase 1 promoter polymorphism with susceptibility to esophageal squamous cell carcinoma and gastric cardiac adenocarcinoma in northern China. World J Gastroenterol 2005; 11(16): 2385-2389
URL: https://www.wjgnet.com/1007-9327/full/v11/i16/2385.htm
DOI: https://dx.doi.org/10.3748/wjg.v11.i16.2385