Differential gene expression during capillary morphogenesis in a microcarrier-based three-dimensional in vitro model of angiogenesis with focus on chemokines and chemokine receptors

Figure 1 Sequential steps of capillary formation. A: MCs coated with HMVECs were embedded in fibrin matrix; B: HMVECs on MCs migrated into the matrix and formed sprouts without detectable lumina; C: Sprouts elongated, and small intracellular or intercellular lumina formed; D: Capillary sprouts anastomosed to each other, and capillary-like network formed (original magnification: A, B, C, ×100; D, ×400).