Nitroester drug’s effects and their antagonistic effects against morphine on human sphincter of Oddi motility

Table 7 Antagonism of PTN against morphine on the SO motility in 10 patients (mean±SD).

	10 min after morphine administration (control)	10 min after PTN associated administration associated	20 min after PTN administration
Sphincter of Oddi basal pressure (mmHg)	13.25±9.63	10.61±11.00	13.12±12.09
Amplitude of phasic contractions (mmHg)	100.64±44.99	75.86±32.16a	66.17±35.88a
Frequency of phasic contractions (n/min)	10.70±2.76	9.95±1.08	9.04±1.71c
Common bile duct pressure (mmHg)	6.99±6.30	6.49±3.66	4.48±4.15

^aP<0.05,

^cP<0.05 vs themselves , n = 10 (n represents the number of patients involved in the research).