Nitroester drug’s effects and their antagonistic effects against morphine on human sphincter of Oddi motility

Table 6 Antagonism of ISDN against morphine on the SO motility in 10 patients (mean±SD).

	10 min after morphine administration (control)	10 min after ISDN associated administration associated	20 min after ISDNadministration
Sphincter of Oddi basal pressure (mmHg)	24.63±19.55	5.43±4.82a	5.98±6.02b
Amplitude of phasic contractions (mmHg)	112.89±35.04	39.65±21.08d	43.45±28.65d
Frequency of phasic contractions (n/min)	11.46±3.83	8.82±2.67	8.52±2.21c
Common bile duct pressure (mmHg)	11.79±8.21	6.05±4.76e	5.75±3.87e

^aP<0.05,

^cP<0.05,

^eP<0.05,

^bP<0.01,

^dP<0.01 vs themselves, n = 10 (n represents the number of patients involved in the research).