Nitroester drug’s effects and their antagonistic effects against morphine on human sphincter of Oddi motility

Table 5 Antagonism of GTN against morphine on the SO motility in 10 patients (mean±SD).

	10 min after morphine administration (control)	10 min after GTN associated administration associated	20 min after GTNadministration
Sphincter of Oddi basal pressure (mmHg)	12.49±5.40	6.46±6.88b	13.47±7.69
Amplitude of phasic contractions (mmHg)	96.56±48.49	56.54±27.19d	63.89±34.56
Frequency of phasic contractions (n/min)	8.98±1.34	6.96±1.83f	7.66±2.50
Common bile duct pressure (mmHg)	10.99±4.75	4.94±3.27h	7.87±4.72

^bP<0.01,

^dP<0.01,

^fP<0.01,

^hP<0.01 vs themselves, n = 10 (n represents the number of patients involved in the research).