Nitroester drug’s effects and their antagonistic effects against morphine on human sphincter of Oddi motility

Table 2 Manometric data before and after administration of ISDN in 16 patients (mean±SD).

	Before ISDN administration (control)	10 min after ISDN administration	20 min after ISDN administration
Sphincter of Oddi basal pressure (mmHg)	10.78±10.79	5.56±3.38a	5.40±4.78
Amplitude of phasic contractions (mmHg)	92.06±43.36	60.82±33.64c	38.16±18.38d
Frequency of phasic contractions (n/min)	7.88±2.58	6.83±3.63	7.13±3.47
Common bile duct pressure (mmHg)	4.49±5.33	3.42±1.56	3.13±2.17

^aP<0.05,

^cP <0.05

^dP<0.01 vs themselves, n = 16 (n represents the number of patients involved in the research).