β-catenin up-regulates the expression of cyclinD1, c-myc and MMP-7 in human pancreatic cancer: Relationships with carcinogenesis and metastasis

Table 1 Relationships between expression of β-catenin, cyclinD1, c-myc and MMP-7 and clinicopathologic characteristics of pancreatic cancer.

Parameter	n	β-catenin		c-myc		cyclinD1		MMP-7
		Normal	Abnormal	+	-	+	-	+	-
Mass size (cm)
<3	9	3	6	6	3	6	3	6	3
3-5	15	4	11	11	4	10	5	10	5
>5	23	8	15	16	7	19	4	14	9
Histological grade
I	10	4	6	5	5	4	6	7	3
II	16	6	10	11	5	12	4	11	5
III	21	5	16	17	4	19a	2	12	9
Proliferation degree
High	28	6	22	23	5	25	3	16	12
Low	19	9	10	10c	9	10c	9	14	5
Metastasis
Positive	25	4	21	19	6	20	5	20	5
Negative	22	11e	11	14	8	15	7	10e	12
Survival time (yr)
>1	13	8	5	8	5	9	4	4	9
≤1	34	7g	27	25	9	26	8	26g	8

^aP<0.05 vs grade I;

^cP<0.05 vs high proliferation degree;

^eP<0.05 vs positive metastases.

^gP<0.05 vs >1 year.