Expression profiling suggests a regulatory role of gallbladder in lipid homeostasis

Table 5 Lipid-related genes expressed in normal gallbladder.

M12792	Cytochrome P450, subfamily XXIA (steroid 21-hydroxylase, congenital adrenal hyperplasia), polypeptide 2	CYP21A2		44.19±7.57
L07077	Enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase	EHHADH		45.78±6.21
BE566894	Human DNA sequence from clone RP11-16L21 on chromosome 9. Contains the gene for NADP-dependent leukotriene B4 12-hydroxydehydrogenase, the gene for a novel DnaJ domain protein similar to Drosophila, C. elegans and Arabidopsis predicted proteins, the GNG10		U1	47.45±1.75
NM_016371	Hydroxysteroid (17-beta) dehydrogenase 7	HSD17B7		48.38±6.73
AF151638	Phosphatidylcholine transfer protein2	PCTP	P3	53.38±6.96
M12529	Apolipoprotein E2	APOE	P3	53.51±9.77
AL034369	Human DNA sequence from clone 149D17 on chromosome Xq22.2-23. Contains part of a PLRP2 (PNLIPRP2, pancreatic lipase-related protein 2 Precursor, EC 3.1.1.3) LIKE gene and 5' exons of the COL4A5 and alternatively spliced COL4A6 genes for Collagen, type IV			54.46±5.61
M22430	Phospholipase A2, group IIA (platelets, synovial fluid)	PLA2G2A	P3	58.57±9.02
AK000339	Long-chain fatty acid Coenzyme A ligase 5	FACL5	U1	58.82±3.86
NM_013389	NPC1 (Niemann–Pick disease, type C1, gene)-like 1	NPC1L1	U1	59.9±13.58
M63959	Low density lipoprotein-related protein-associated protein 1 (alpha-2-macroglobulin receptor-associated protein 1)2	LRPAP1	U1	60.24±6.70
AF263613	Intracellular membrane-associated calcium-independent phospholipase A2 gamma	IPLA2(GAMMA)		60.96±13.23
Z29481	3-Hydroxyanthranilate 3,4-dioxygenase	HAAO		62.47±0.09
D38081	Thromboxane A2 receptor	TBXA2R		66.03±19.67
X71973	Glutathione peroxidase 4 (phospholipid hydroperoxidase)	GPX4		69.27±12.44
AW662196	Apolipoprotein L, 2	APOL2	P3	79.49±5.89
AI590076	3-Hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble)	HMGCS1	P3	83.08±4.33
AL022398	Homo sapiens DNA sequence from PAC 434O14 on chromosome 1q32.3.-41. Contains the HSD11B1 gene for hydroxysteroid (11-beta) dehydrogenase 1, the ADORA2BP adenosine A2b receptor LIKE pseudogene, the IRF6 gene for Interferon Regulatory Factor 6 and two novel			85.30±14.15
AL022394	Phospholipase C, gamma 1 (formerly subtype 148)	PLCG1	P3	85.54±21.21
Z82215	Apolipoprotein L	APOL1	U1	89.89±16.36
J02611	Apolipoprotein D	APOD		92.61±8.90
U19487	Prostaglandin E receptor 2 (subtype EP2), 53 ku	PTGER2	P3	95.40±18.27
X59812	Cytochrome P450, subfamily XXVIIA (steroid 27-hydroxylase, cerebrotendinous xanthomatosis), polypeptide 12	CYP27A1	P3	100.70±10.81
AF070675	Apolipoprotein L, 3	APOL3	U1	105.58±12.73
U00968	Sterol regulatory element binding transcription factor 12	SREBF1	P3	107.4±8.65
AB018580	Aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid	AKR1C3 dehydrogenase, type II)2	P3	110.69±31.00
X98332	Solute carrier family 22 (organic cation transporter), member 12	SLC22A1	P3	112.02±22.09
M10617	Fatty acid binding protein 1, liver2	FABP1	U1	117.5±11.59
L11702	Glycosylphosphatidylinositol specific phospholipase D1	GPLD1		149.16±33.78
X06290	Lipoprotein, Lp(a)	LPA	P3	156.94±26.59
X14723	Clusterin (complement lysis inhibitor, SP-40,40, sulfated glycoprotein 2, testosterone-repressed prostate message 2, apolipoprotein J)	CLU	U1	163.92±11.19
BE018577	3-Hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble)	HMGCS1	P3	169.72±16.05
U23942	Cytochrome P450, 51 (lanosterol 14-alpha-demethylase)	CYP51		219.74±47.13
AL049547	Cytochrome P450, subfamily XXIA (steroid 21-hydroxylase, congenital adrenal hyperplasia), polypeptide 2	CYP21A2		246.11±42.36
AF081281	Lysophospholipase I	LYPLA1	P3	348.56±34.15
L40802	Hydroxysteroid (17-beta) dehydrogenase 2	HSD17B2		396.94±5.65

¹U: Genes expressed in the gallbladder through searching Unigene Database;

²Gallstone candidate genes;

³P: Genes expressed in the gallbladder suggested by previous report.