Expression profiling suggests a regulatory role of gallbladder in lipid homeostasis

Table 3 Lipid-related genes expressed in normal gallbladder.

U68233	Nuclear receptor subfamily 1, group H, member 4**	NR1H4		16.80±0.65
AF035284	Fatty acid desaturase 1	FADS1	U1	16.82±0.92
X04898	Apolipoprotein A-II	APOA2	U1	16.96±2.01
AL031295	Lysophospholipase II	LYPLA2	P3	17.01±0.19
AL031295	3-Hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (hydroxymethylglutaricaciduria)	HMGCL		17.01±0.19
M55150	Fumarylacetoacetate hydrolase (fumarylacetoacetase)	FAH		17.41±2.04
M31210	Endothelial differentiation, sphingolipid G-protein-coupled receptor, 1	EDG1		17.56±0.62
BE395256	Lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)	LSS		17.63±1.71
NM_000483	Apolipoprotein C-II	APOC2	U1	17.71±1.70
L76465	Hydroxyprostaglandin dehydrogenase 15-(NAD)	HPGD		17.86±0.79
S68287	Aldo-keto reductase family 1, member C4 (chlordecone reductase 3-alpha hydroxysteroid dehydrogenase, type I dihydrodiol dehydrogenase 4)	AKR1C4	P3	18.11±2.89
M54927	Proteolipid protein 1 (Pelizaeus-Merzbacher disease, spastic paraplegia 2, uncomplicated)	PLP1	P3	18.21±1.67
BE714757	Lipase A, lysosomal acid, cholesterol esterase (Wolman’s disease)	LIPA		18.26±2.02
AJ238243	Phospholipase A2-activating protein	PLAA		18.73±3.07
AF077820	Low density lipoprotein receptor-related protein 5	LRP5		18.98±2.79
AL031778	Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2	APOBEC2	P3	19.21±3.45
AC004770	Fatty acid desaturase 1	FADS1	U1	19.22±9.65
AC004770	Fatty acid desaturase 3	FADS3		19.22±9.65
AA280051	Fatty acid binding protein 1, liver	FABP1	U1	19.81±3.80
X67698	Niemann–Pick disease, type C2 gene	NPC2		20.53±1.84
AL049748	Apolipoprotein L, 5	APOL5		20.61±0.01
X51416	Estrogen-related receptor alpha	ESRRA		20.63±1.82
AF065215	Phospholipase A2, group IVB (cytosolic)	PLA2G4B	P3	20.71±3.25
AB006746	Phospholipid scramblase 1	PLSCR1	U1	21.33±0.62
M59979	Prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	PTGS1	P3	21.55±0.74
X02162	Apolipoprotein A-I	APOA1	U1	21.70±0.75
AF079167	Oxidised low density lipoprotein (lectin-like) receptor 1	OLR1	P3	22.12±7.75
U55764	Sulfotransferase, estrogen-preferring	STE		22.15±2.72
J03459	Leukotriene A4 hydrolase	LTA4H		22.32±4.28
U03090	Phospholipase A2, group V	PLA2G5	P3	22.88±2.74
M76665	Hydroxysteroid (11-beta) dehydrogenase 1	HSD11B1	P3	22.98±3.71
NM_016108	Androgen induced protein	AIG-1	P3	23.02±3.33
AV651650	ESTs, highly similar to AF237982 1 oxysterol 7 alpha-hydroxylase [H.sapiens]			23.62±0.57
U11313	Sterol carrier protein 22	SCP2	U1	23.92±0.18
NM_001645	Apolipoprotein C-I	APOC1	U1	25.02±12.59
X54741	Cytochrome P450, subfamily XIB (steroid 11-beta-hydroxylase), polypeptide 2	CYP11B2		25.13±3.81
X01388	Apolipoprotein C-III	APOC3		25.17±4.82
R98624	Bile acid Coenzyme A: amino acid N-acyltransferase (glycine N-choloyltransferase)	BAAT	P3	25.26±16.74
U93305	Proteolipid protein 2 (colonic epithelium-enriched)	PLP2	P3	25.41±2.44
U67963	Lysophospholipase-like	HU-K5		26.75±5.28
D86096	Prostaglandin E receptor 3 (subtype EP3)	PTGER3	P3	26.79±0.19
AL022398	Hydroxysteroid (11-beta) dehydrogenase 1	HSD11B1		26.82±8.70
X76488	Lipase A, lysosomal acid, cholesterol esterase (Wolman’s disease)	LIPA		27.10±11.84
AF019225	Apolipoprotein L	APOL1	U1	28.12±1.76
AL034374	Homolog of yeast long chain polyunsaturated fatty acid elongation enzyme 2	HELO1		28.76±4.09
AI675602	EST, moderately similar to I65981 fatty acid omega-hydroxylase [H.sapiens]			28.85±13.77
U89281	Oxidative 3 alpha hydroxysteroid dehydrogenase; retinol dehydrogenase; 3-hydroxysteroid epimerase	RODH		29.09±7.19
AL022318	Phorbolin (similar to apolipoprotein B mRNA editing protein)	DJ742C19.2		29.26±5.26
X07228	Lipase, hepatic	LIPC	P3	30.57±4.34
AL031230	Glycosylphosphatidylinositol specific phospholipase D1	GPLD1		30.88±1.21
AA128778	Tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)	TFPI		32.76±0.09
Z99390	L-3-hydroxyacyl-Coenzyme A dehydrogenase, short chain	HADHSC		33.87±0.98
AF002020	Niemann–Pick disease, type C12	NPC1		34.88±12.12
X55764	Cytochrome P450, subfamily XIB (steroid 11-beta-hydroxylase), polypeptide 1	CYP11B1		34.95±1.61
L34081	Bile acid Coenzyme A: amino acid N-acyltransferase (glycine N-choloyltransferase)	BAAT	P3	37.8±3.91
AF002668	Degenerative spermatocyte (homolog Drosophila lipid desaturase)	DEGS		37.93±4.50
AF034544	7-Dehydrocholesterol reductase	DHCR7		38.05±2.80
D82073	Prostaglandin D2 synthase, hematopoietic	PGDS		38.83±13.58
Z37986	Emopamil-binding protein (sterol isomerase)	EBP		41.25±12.24
L21934	Sterol O-acyltransferase (acyl-Coenzyme A: cholesterol acyltransferase) 1	SOAT1	P3	44.08±1.76
L21934	Sterol O-acyltransferase (acyl-Coenzyme A: cholesterol acyltransferase) 12	SOAT1	P3	44.08±1.76

¹U: Genes expressed in the gallbladder through searching Unigene Database;

²Gallstone candidate genes;

³P: Genes expressed in the gallbladder suggested by previous report.