Expression profiling suggests a regulatory role of gallbladder in lipid homeostasis

Table 2 Lipid-related genes expressed in normal gallbladder.

GenBank ID	Gene name	Symbol	Reported or not	Gray level (mean±SD)
NM_000859	3-Hydroxy-3-methylglutaryl-Coenzyme A reductase2	HMGCR	P3	10.98±0.31
U66669	3-hydroxyisobutyryl-Coenzyme A hydrolase	HIBCH		11.17±0.09
U29344	Fatty acid synthase	FASN		11.42±2.62
AA460901	ATPase, aminophospholipid transporter-like, Class I, type 8A, member 2	ATP8A2		11.53±1.08
BE730527	Lipase protein	LOC57406	P3	11.58±0.85
AL043165	Homolog of mouse transient receptor potential-phospholipase; C-interacting kinase CHaK; hypothetical protein FLJ20117	LTRPC7		11.59±0.69
U22662	Nuclear receptor subfamily 1, group H, member 32	NR1H3		11.77±0.85
M14564	Cytochrome P450, subfamily XVII (steroid 17-alpha-hydroxylase), adrenal hyperplasia	CYP17		12.06±1.35
M93107	3-Hydroxybutyrate dehydrogenase (heart, mitochondria)	BDH	P3	12.10±2.22
NM_019844	Solute carrier family 21 (organic anion transporter), member 82	SLC21A8	P3	12.14±0.77
AK000184	Acid sphingomyelinase-like phosphodiesterase	ASM3A		12.22±0.65
±X04506	±Apolipoprotein B (including Ag(x) antigen)	APOB	U1	12.23±1.17
X87176	Hydroxysteroid (17-beta) dehydrogenase 4	HSD17B4	U1	12.25±0.57
AF095703	L-3-hydroxyacyl-Coenzyme A dehydrogenase, short chain	HADHSC		12.37±1.66
AW022180	ESTs, weakly similar to S14747 sphingomyelin phosphodiesterase [H. sapiens]			12.39±2.40
U32576	Apolipoprotein C-IV	APOC4	U1	12.58±0.28
AI133376	Human DNA sequence from clone RP11-16L21 on chromosome 9. Contains the gene for NADP-dependent leukotriene B4 12-hydroxydehydrogenase, the gene for a novel DnaJ domain protein similar to Drosophila, C. elegans and Arabidopsis predicted proteins, the GNG10			12.75±1.64
AV658073	Homolog of mouse transient receptor potential-phospholipase C-interacting kinase CHaK	hypothetical protein FLJ20117	LTRPC7	12.83±1.45
X03635	Estrogen receptor 1	ESR1		12.83±0.34
AF165514	Hydroxysteroid (17-beta) dehydrogenase 7	HSD17B7	P3	12.99±0.56
NM_018557	Low density lipoprotein-related protein 1B (deleted in tumors)	LRP1B		13.06±0.29
U22526	Lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)	LSS		13.14±0.70
X83618	3-Hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial)	HMGCS2	P3	13.34±0.03
D14662	Anti-oxidant protein 2 (non-selenium glutathione peroxidase, acidic calcium-independent phospholipase A2)	KIAA0106	U1	13.40±0.78
M62839	Apolipoprotein H (beta-2-glycoprotein I)	APOH		13.49±0.20
Z99716	Sterol regulatory element binding transcription factor 22	SREBF2	P3	13.53±2.31
AF126799	Fatty acid desaturase 2	FADS2		13.62±2.16
AV662152	EST, moderately similar to LPHUC1 apolipoprotein C-I precursor [H. sapiens]			13.63±1.57
M37238	Phospholipase C, gamma 2 (phosphatidylinositol-specific)	PLCG2	P3	13.79±2.16
AF129756	Apolipoprotein M G3A			13.90±0.29
AW873435	Lipase A, lysosomal acid, cholesterol esterase (Wolman’s disease)	LIPA		13.98±1.71
U09117	Phospholipase C, delta 1	PLCD1	P3	14.06±0.58
AC007954	Glutathione transferase zeta 1 (maleylacetoacetate isomerase)	GSTZ1		14.13±0.76
AA706930	Fatty acid binding protein 1, liver	FABP1	U1	14.19±0.25
AB011153	Phosphoinositide-specific phospholipase C-beta 1	PLCB1		14.65±2.22
AF038440	Phospholipase D2	PLD2		14.66±5.01
N42553	Homolog of mouse transient receptor potential-phospholipase C-interacting kinase CHaK	hypothetical protein FLJ20117	LTRPC7	14.68±2.50
AL110209	LCAT-like lysophospholipase		LLPL	14.88±2.24
X13916	Low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor)2	LRP1		14.91±1.56
AI955289	ESTs, weakly similar to DXHUBH 11beta-hydroxysteroid dehydrogenase [H.sapiens]			14.96±1.66
AF077046	Ganglioside expression factor 2	GEF-2		15.11±1.98
Z34975	Low density lipoprotein receptor defect C complementing	LDLC		15.18±2.11
BE271295	Group XII secreted phospholipase A2	PLA2G12		15.64±1.27
U49248	ATP-binding cassette, sub-family C (CFTR/MRP), member 22	ABCC2	U1	15.78±0.45
N78156	Homolog of yeast long chain polyunsaturated fatty acid elongation enzyme 2	HELO1		15.95±5.40
AB016247	Sterol-C5-desaturase (fungal ERG3, delta-5-desaturase)-like	SC5DL	P3	16.09±3.33
NM_000954	Prostaglandin D2 synthase (21 ku, brain)	PTGDS		16.19±3.18
U60205	Sterol-C4-methyl oxidase-like	SC4MOL		16.22±1.29
AA557324	ESTs, weakly similar to fatty acid omega-hydroxylase [H.sapiens]			16.31±2.98
X66435	3-Hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble)	HMGCS1	P3	16.46±2.32
AL117352	Human DNA sequence from clone RP5-876B10 on chromosome 1q42.12-43. Contains the 3' end of the GNPAT gene for glyceronephosphate O-acyltransferase (DHAPAT, DAPAT, dihydroxyacetone phosphate acyltransferase, EC 2.3.1.42), the gene for a novel protein (ortho)			16.74±0.16
BE737965	Caveolin 1, caveolae protein, 22 ku2	CAV1		16.74±2.50

¹U: Genes expressed in the gallbladder through searching Unigene Database;

²Gallstone candidate genes;

³P: Genes expressed in the gallbladder suggested by previous report.