Expression of heat shock proteins (HSP27, HSP60, HSP70, HSP90, GRP78, GRP94) in hepatitis B virus-related hepatocellular carcinomas and dysplastic nodules

Table 4 Correlation between HSP immunostaining and prognostic factors in 38 HCCs.

	P
	HSP27	HSP60	HSP70	HSP90	GRP78	GRP94
Histological grade
E–HCC (5)
HCC GI (12)	0.150	0.085	0.0091	0.0001	0.0001	0.0001
HCC GII (11)
HCC GIII (10)
Tumor size
≤2 cm (10)	0.097	0.158	0.077	0.079	0.0001	0.0191
>2 cm (28)
Encapsulation
E-HCC (5)
Positive (27)	0.434	0.634	0.0491	0.0011	0.0111	0.0051
Negative (6)
Microvascular invasion
Positive (16)	0.413	0.339	0.0421	0.0001	0.0021	0.0001
Negative (22)
Major portal vein invasion
Positive (3)	0.271	0.489	0.739	0.0121	0.0501	0.0281
Negative (35)
Intrahepatic metastasis
Positive (7)	0.798	0.189	0.158	0.0001	0.0101	0.0501
Negative (31)
Tumor stage I (25)
II (10)	0.800	0.816	0.128	0.0001	0.0021	0.0001
III (3)

E: early; G: Edmondson-Steiner’s grade; ( ): number of cases; P: Jonckheere-Terpstra test, Mann–Whitney test, or Kruskal–Wallis test;

¹Value was statistically significant.