Expression of heat shock proteins (HSP27, HSP60, HSP70, HSP90, GRP78, GRP94) in hepatitis B virus-related hepatocellular carcinomas and dysplastic nodules

Table 3 Enhancement of HSP expression relative to non-tumorous tissue in hepatocarcinogenesis obtained by dot immunoblot analysis.

Group	n	Enhancement of expression (mean±SD)
		HSP27	HSP60	HSP70	HSP90	GRP78	GRP94
LGDN	11	1.25±0.31	1.07±0.43	1.37±0.45	1.55±0.45	1.65±0.85	1.61±1.02
HGDN	8	1.22±0.72	1.15±0.44	1.32±0.58	1.20±0.32	1.42±0.71	2.45±1.87
E-HCC	5	2.52±1.57	0.93±0.41	1.18±0.49	1.04±0.64	1.72±1.16	1.63±0.54
HCC GI	12	2.17±1.06	1.96±1.20	2.69±1.72	2.76±1.70	7.41±8.65	13.70±25.68
HCC GII	11	3.26±3.19	1.58±0.41	1.80±0.55	1.95±0.56	2.65±1.30	1.87±0.90
HCC GIII	10	2.68±2.34	2.14±1.58	1.66±0.84	2.22±1.33	4.54±4.79	3.02±2.70
P		0.0181	0.0041	0.123	0.0211	0.0051	0.373

LGDN: low-grade dysplastic nodule; HGDN: high-grade dysplastic nodule; E: early; HCC: hepatocellular carcinoma; G: Edmondson-Steiner’s grade; n: number of cases; SD: standard deviation; P: Jonckheere-Terpstra test;

¹Value was statistically significant.