Expression of heat shock proteins (HSP27, HSP60, HSP70, HSP90, GRP78, GRP94) in hepatitis B virus-related hepatocellular carcinomas and dysplastic nodules

Table 2 Expression of HSPs in hepatocarcinogenesis obtained by dot immunoblot analysis.

HSP	Tumor/ non-tumor	DN		HCC				P (r)
		LGDN (n = 11)	HGDN (n = 8)	E-HCC (n = 5)	GI (n = 12)	GII (n = 11)	GIII (n = 10)
HSP27	< 0.5		1	1
	0.5-1.5	9	6		3	4	4	0.0021
	1.5-2.5	2	1	2	6	2	2	(0.407)
	> 2.5			2	3	5	4
HSP60	< 0.5				1
	0.5-1.5	10	6	4	4	5	4	0.0041
	1.5-2.5	1	2	1	4	6	4	(0.372)
	> 2.5				3		2
HSP70	< 0.5
	0.5-1.5	6	7	3	3	2	5	0.100
	1.5-2.5		5	2	4	8	4	(0.220)
	> 2.5		1		5	1	1
HSP90	< 0.5			1
	0.5-1.5	5	6	3	2	2	2	0.0071
	1.5-2.5	6	2	1	4	7	6	(0.353)
	> 2.5				6	2	2
	GRP78 < 0.5		1				1
	0.5-1.5	5	3	3	2	3	2	0.0071
	1.5-2.5	5	4	1	4	3		(0.355)
	> 2.5	1		1	6	5	7
GRP94	< 0.5						1
	0.5-1.5	7	1	2	1	5	4	0.571
	1.5-2.5	2	6	3	5	4	1	(0.077)
	> 2.5	2	1		6	2	4

DN: dysplastic nodule; LGDN: low-grade DN; HGDN: high-grade DN; HCC: hepatocellular carcinoma; E: early; G: Edmondson-Steiner’s grade; n: number of cases; P: Spearman Correlation; (r): Correlation coefficient;

¹Value was statistically significant.