Expression of heat shock proteins (HSP27, HSP60, HSP70, HSP90, GRP78, GRP94) in hepatitis B virus-related hepatocellular carcinomas and dysplastic nodules

Table 1 Expression of HSPs in hepatocarcinogenesis obtained by IHC analysis.

HSP	Percentage of positive cells (%)	NL (n = 57)	DN		HCC				P (r)
			LGDN (n = 11)	HGDN (n = 8)	E-HCC (n = 5)	GI (n = 12)	GII (n = 11)	GIII (n = 10)
HSP27	0-5	42	11	6		5	2	2
	6-25	12		2	4	5	3	3	0.0001
	26-50	3					2	1	(0.600)
	51-75				1	1	2
	>75					1	2	4
HSP60	0-5							1
	6-25								0.0121
	26-50	3					3		(-0.329)
	51-75	2						1
	>75	52	11	8	5	12	8	8
HSP70	0-5	57	11	8	3	4	3	2
	6-25				1	3	2		0.0001
	26-50				1	3	2	1	(0.669)
	51-75					1	2	4
	>75					1	2	3
HSP90	0-5	56	10	8	5	8	4
	6-25	1	1			2	4	3	0.0001
	26-50					2	2	3	(0.707)
	51-75						1	2
	>75					2
GRP78	0-5	5	6	1	1	1
	6-25	22	5	7	4	5	2		0.0001
	26-50	17				1	2	1	(0.802)
	51-75	9				3	2	1
	>75	4				2	5	8
GRP94	0-5	16	3	3	2	1	2
	6-25	26	7	4	2	2			0.0001
	26-50	9	1	1	1	7	3	2	(0.708)
	51-75	3				1	3
	>75	3				1	3	8

NL: non-tumorous liver; DN: dysplastic nodule; LGDN: low-grade DN; HGDN: high-grade DN; HCC: hepatocellular carcinoma; E: early; G: Edmondson-Steiner’s grade; n: number of cases; P: Spearman correlation (from LGDN to HCC GIII); (r): Correlation coefficient;

¹Value was statistically significant.