Loss of heterozygosity in multistage carcinogenesis of esophageal carcinoma at high-incidence area in Henan Province, China

Table 1 Comparison between frequency of microsatellite LOH in different lesions of esophagus.

MSM	LOH frequency n (%)				P
	BCH	DYS	CIS	SCC
D3S1234	1/14 (7.1)	3/12 (25)	5/15 (33.30)	9/23 (39.1)	0.042
D3S1300	0/11 (0)	2/10 (20)	4/10 (40)	10/26 (38.5)	0.024
D3S966	0/13 (0)	3/13 (23.1)	8/16 (50)	11/20 (55.0)	0.001
D5S82	0/12 (0)	2/12 (16.7)	6/15 (40)	8/20 (40.0)	0.010
D5S346	2/12 (16.7)	3/12 (25)	4/10 (40)	14/25 (56.0)	0.011
D6S497	0/10 (0)	0/13 (0)	0/12 (0)	9/26 (34.6)	0.001
D9S1752	1/15 (6.7)	2/12 (16.7)	3/15 (20)	5/25 (20.0)	0.315
D9S171	0/13 (0)	5/16 (31.3)	7/14 (50)	14/23 (60.8)	0.000
D13S233	0/11 (0)	3/13 (23.1)	6/16 (37.5)	10/21 (47.6)	0.006
D13S321	0/14 (0)	3/12 (25)	6/14 (42.9)	11/25 (44.0)	0.006
D13S260	0/16 (0)	4/12 (33.3)	7/14 (50)	16/26 (61.5)	0.000
D17S855	2/13 (15.4)	4/14 (28.6)	6/15 (40)	14/26 (53.8)	0.014
TP53	3/15 (20)	4/13 (30.8)	7/16 (43.8)	15/22 (68.2)	0.002
D17S786	0/14 (0)	3/12 (25)	6/15 (40)	12/22 (54.5)	0.001
D18S858	0/13 (0)	3/16 (18.8)	4/12 (33.3)	10/18 (55.6)	0.000

MSM: microsatellite marker; LOH: loss of heterozygosity; BCH: basal cell hyperplasia DYS: dysplasia; CIS: carcinoma in situ; SCC: squamous cell carcinoma -: not done.