Cytochrome p450 2E1 polymorphisms and the risk of gastric cardia cancer

Table 3 Associations of cardia cancer risk with joint distribution of CYP2E1 genotypes and smoking status.

Smoking status	CYP2E1	Cases		Controls		OR (95%CI)1	OR (95%CI)2
		n	%	n	%
Smoking
Never	c1/c2 or c2/c2	33	20.75	55	28.65	1	1
Ever	C1/c1	35	22.01	53	27.60	1.05 (0.561.99)	1.03 (0.522.06)
Ever	c1/c2 or c2/c2	30	18.87	60	31.25	0.85 (0.401.78)	0.91 (0.392.14)
Ever	C1/c1	61	38.36	24	12.50	4.68 (2.1910.04)	3.94 (1.609.67)
Daily consumed cigarettes
1-19	c1/c2 or c2/c2	8	5.03	15	7.81	0.81 (0.272.39)	0.62 (0.182.16)
1-19	C1/c1	9	5.66	6	3.13	2.99 (0.8810.19)	2.59 (0.5412.45)
≥20	c1/c2 or c2/c2	22	13.84	45	23.44	0.90 (0.411.98)	1.04 (0.412.67)
≥20	C1/c1	52	32.70	18	9.38	5.34 (2.3811.95)	4.17 (1.6310.63)
Smoking duration (yr)
1-29	c1/c2 or c2/c2	10	6.29	25	13.02	0.71 (0.271.87)	0.82 (0.272.49)
1-29	C1/c1	19	11.95	18	9.38	2.10 (0.855.21)	1.99 (0.616.49)
≥30	c1/c2 or c2/c2	20	12.58	35	18.23	1.10 (0.472.57)	1.00 (0.372.69)
≥30	C1/c1	42	26.42	6	3.13	13.32 (4.5039.45)	8.44 (2.5827.59)

¹Odds ratios adjusted for age (continuous), gender and educational level.

²Odds ratios adjusted for age (continuous), gender, educational level, family cancer history, vegetables and fruit consumption, picked and salted food consumption, alcohol consumption, and refrigerator use.