Genetic distinctions between autoimmune hepatitis in Italy and North America

Table 2 Comparison of class I and class II HLA in Italian patients and controls (n, %).

HLA	Type 1 AIH (57 cases)	Type 2 AIH (17 cases)	Controls (250 BD)	PI	PII	PIII
B8	18 (32)	3 (18)	138 (10)	<0.0001	NS	NS
C7	29 (51)	7 (41)	270 (20)	<0.0001	NS	NS
DR3	17 (30)	5 (29)	32 (13)	0.004	NS	NS
DR4	13 (23)	4 (23)	41 (16)	NS	NS	NS
DR7	9 (16)	6 (35)	72 (29)	NS	NS	NS
DR11	10 (17)	7 (41)	87 (35)	0.01	NS	NS
DR13	15 (26)	1 (6)	65 (23)	NS	NS	NS
DQ2	30 (53)	9 (53)	75 (30)	<0.0001	NS	NS
B8–DR3–DQ2	17/57 (30)	2 (12)	323 (7)	<0.0001	NS	NS

Test used: Fisher’s exact test. AIH: autoimmune hepatitis. BD: blood donors. P_I: type 1 AIH vs controls, P_II: type 2 AIH vs controls, P_III: type 1 AIH vs type 2 AIH. ¹Evaluated on a sample of 372 controls. ²Evaluated on a sample of 350 controls. ³Evaluated on a sample of 337 controls.